With the increase of work and life pressure, the prevalence of cardiac neurosis in creases year by year. After studying the theory of "qi and blood pathogenesis" in ancient medical works, the author compares the treatment range of Xuefu Zhuyu decoction with that of cardiac neurosis defined by modern medicine, and finds that Xuefu Zhuyu decoction is suitable for the treatment of cardiac neurosis. The authorused acupuncture and medicine to treat patients with cardiac neurosis. After studying the rationality and advanced nature of Xuefu Zhuyu decoction combined with acupuncture and moxibustion therapy in clinical application, it was found that the treatmentis effective in the treatment of patients with cardiac neurosis caused by "qi and blood" . It has obvious curative effect and practical significance of clinical popularization.