On the basis of previous experience and years of clinical and scientific research experience, Professor MAO Dewen summed up the new theory of "toxin-turbid causing liver failure" , and believed that "toxin" was the cause of the disease, "turbid" was the pathological product, and "Yang deficiency" was the root of the disease.The interaction of "toxin" , "turbid" and "deficiency" and the stagnation of the three ultimately lead to the onset and development of liver failure, highly revealing the nature of the disease.It summarizes the three treatment principles of "truncation reversal" , "supporting Yang and cultivating the soil" and "dredging Fu organs and opening orifices" , and refines the "truncation reversal" treatment scheme of traditional Chinese medicine/integrated traditional Chinese and Western medicine dominated by Jiedu Huayu Granule(解毒化瘀颗粒)for acute(subacute)liver failure and chronic and acute liver failure, the traditional Chinese medicine/integrated traditional Chinese and Western medicine treatment scheme represented by Yinchen Zhufu Decoction(茵陈术附汤)for chronic liver failure with the "supporting Yang and cultivating the soil" method, and the traditional Chinese medicine treatment scheme centered on Jiedu Huayu Granule(解毒化瘀颗粒)combined with external Rhubarb decoction enema for hepatic encephalopathy with the "dredging Fu organs and opening orifices" method.The clinical application shows that the scheme has good clinical effect.