Proteinuria is an independent risk factor that accelerates kidney disease and affects the prognosis of patients with kidney disease. A large amount of protein loss will cause the patients'plasma albumin to decrease, immune function to decrease, and symptoms such as edema. In the idea of traditional Chinese medicine, proteinuria is caused by the damage of lung, spleen and kidney, also it can be caused by damp, congestion and wind. Therefore, traditional Chinese medicine treatments includes restoring functionality of spleen and kidney to clear the damp-heat, and removing the congestion and wind. Professor CAO Shili believes that the disease of proteinuria is in the kidney venation, and kidney collateral deficiency is defined as original cause while congealing is the superficial cause, combined with the theory of collateral disease in the treatment of proteinuria, different methods should be adopted as a therapeutic method in the process of proteinuria. The general characteristics of collateral diseases is collaterals obstruction, so Professor CAO treats proteinuria by clearing damage and recovering functionality. Damp-heat syndrome is a common syndrome in the protracted period of chronic kidney disease. Damp-heat syndrome plays an important role in the pathogenesis of chronic glomerular disease, and its reduction is closely related to changes in proteinuria. Deficiency of lung, spleen and kidney is the main internal cause of proteinuria, and damp-heat is an important factor of proteinuria. Based on the TCM pathogenesis of proteinuria and syndrome differentiation, clearing the damp-heat and recovering functionality is the most commonl-used method of professor CAO Shili and has achieved good results in clinical practice.