Heart failure was a complex group of clinical syndromes that led to impaired ventricular filling or impaired ejection ability due to abnormal heart structure or function. It was a serious and end stage of various heart diseases. The end stage of heart failure could be accompanied by three branches of coronary heart disease, renal failure, gastrointestinal bleeding and other modern medical treatments for difficult diseases. The treatment of heart failure with traditional Chinese medicine could significantly improve the symptoms of heart failure, reduce rehospitalization rates and improve the survival rates. Danggui Sini Decoction (当归四逆汤) is derived from ,Treatise on Febrile and Miscellaneous Diseases,. After using Danggui Sini Decoction to treat patients with end - stage heart failure combined with many treatments for thorny diseases, the patients' heart failure symptoms and indicators had been significantly improved. Combined with modern literature pharmacological research, it proved the advantages of classical prescriptions treating end - stage heart failure with many diseases. Taking Danggui Sini Decoction for the treatment of patients with end - stage heart failure as an example, according to the clinical evolution of heart failure, the mechanism of heart failure and the principles of heart failure treatment were explained from the perspective of the six meridians, providing a certain reference for the progress of clinical prevention and treatment of heart failure.