The obsessive-compulsive disorder is a type of mental disorder characterized by obsessive-compulsive concepts and compulsive behaviors. It is characterized by the coexistence of conscious compulsion and anti-compulsion.The clinical manifestations, occurrence and development of the obsessive-compulsive disorder are closely related to the lungs and kidneys in the five internal organs. The physiology of the lungs and kidneys is explored from the aspects of lung storage of Qi, Qi-shelving, kidneys storing essence,Jing, housing the will, and from the physiological basis of the relationship between lungs and kidneys. The obsessive-compulsive disorder is located in the lungs and kidneys. Lung-kidney Qi deficiency is the cause of the disease. Lung deficiency and soul disturbance and kidney deficiency with a weak will are the core pathogenesis, and the basic treatment is to invigorate the lungs and kidneys. In terms of treatment, it focuses on invigorating the lungs and strengthening the spirit, strengthening the kidneys and strengthening the will. Under the guidance of the thoery that bitterness desires supplementation and purgation in the lungs and kidneys, and taking into account the physiological characteristics of the lungs and the kidneys, sour and bitter medicinals were used to supplemement. Combined with clinical cases, the treatment of obsessive-compulsive disorder is presented based on the theory bitterness desires supplementation and purgation in the lungs and kidneys.