National TCM master XUE Boshou focuses on the clinical application of chronic gastritis by distinguishing the deficiency and excess of cold and heat in the viscera, setting stimulating and reducing Yangming as the treatment principle, and attaching importance to the clinical application of “qi supplemented by regulating, and blood supplemented by harmony“ . This article preliminary summarized Professor XUE’s experience in treating chronic gastritis based on differentiation and treatment, introduced his commonly used prescriptions and syndrome differentiation ideas, and gave examples and explanations through proven cases, which can be used for clinical reference.