In clinic, Alzheimer's disease is a common progressive neurodegenerative disease in the elderly population, which is mainly characterized by the decline of memory and cognitive ability, social disorder, abnormal behavior and personality changes. The disease is located in the brain and kidneys, and its pathogenic factors involves three aspects: de fi ciency, phlegm, and blood stasis, with de fi ciency as the root cause, and phlegm and blood stasis as the manifestations. Since the disease is usually manifested as unconsciousness due to the kidney failure and nourishment loss in brain marrow as one grows old, supplementing and boosting drugs are mostly preferred, and tonifying the kidney, nourishing the essence and replenishing the marrow is maintained as the basic treatment principle. Decoction, made of velvet antler slices for 3 g, tortoise plastron for 15 g and a piece of bovine spinal cord, is commonly used to replenish the marrow and nourish the brain, improve the mind and kidney function. After long-term use, it can signi fi cantly improve the quality of life, with a good safety. The therapy renders the clinical TCM treatment of senile dementia feasible.