Summary of case history,　Patient Wei Mou, male, 29 years old, was diagnosed with chronic hepatitis B in 2017. He stopped using antiviral drugs on his own four months ago, and felt yellow in body, eyes and urine three days ago. He was treated in a local clinic, and the curative effect was not good. Now he is hospitalized for further diagnosis and treatment.,TCM diagnosis,　Traditional Chinese medicine diagnosis: jaundice, amp-heat accumulation, blood stasis and toxin syndrome. Western medicine diagnosis: acute-on-chronic liver failure jaundice.,Therapeutis methods,　Western medicine treatment includes symptomatic treatment such as protecting liver, reducing jaundice, reducing enzyme and resisting virus, and infusion of plasma, albumin, etc. The specific drugs include: adenosylmethionine, magnesium isoglycyrrhizinate injection, polyene phosphatidylcholine injection, ursodeoxycholic acid capsule and tenofovir disoproxil fumarate (imported); In the early stage of TCM treatment, the methods of clearing heat and promoting diuresis, removing blood stasis and detoxicating were used, and in the later stage, the methods of invigorating qi and strengthening spleen, promoting blood circulation and removing blood stasis were used, and the treatment was based on syndrome differentiation.,Clinical outcomes,　The symptoms and signs of the patients improved obviously, and the liver function improved obviously, among which transaminase and bilirubin decreased obviously. Coagulation function gradually recovered; Meet the clinical discharge standards.