The ischemic ulcer of diabetic lower limb with ineffective vascular reconstruction refers to the severe limb ischemic ulcer secondary to diabetes mellitus combined with lower extremity arterial disease through surgical bypass or endovascular treatment. Wound pain and difficulty to heal are its main symptoms, which belong to gangrene in traditional Chinese medicine. Based on the theory of meridians and collaterals, Prof. Lyu Peiwen pointed out that the basic pathogenesis of the disease is deficiency of the spleen, kidneys, heart qi, blood and yin-yang deficiency. The excess is characterized by toxin and stasis, which involve the dampness, phlegm and heat. Prof. Lyu Peiwen regulated the constitution and the microenvironment for the lesions through reviving yang to generate muscles, activating blood to generate muscles and transforming the rotted to generate muscles. Simultaneously, two therapeutic methods of replenishing and relieving collaterals were applied to reconstruct blood circulation, which was key to the treatment.