Infectious fever is a common clinical disease in children. Treating fever as early as possible is one of the important goals for the treatment of infectious fever in children. Professor Peng Jianzhong, who studied under Professor Zhao Shaoqin, a well-known doctor in the field of Warm Diseases, clinically applies the theory of Warm Diseases to treat infectious fever in children. He is skilled in using the paired herbs of Periostracum cicadae-Mulberry Silkworm as the main drugs, and he modifies the prescription based on differentiation of Qi and blood, and obtains better efficacy. This article is the theoretical basis and historical evolution of the paired herbs of Periostracum cicadae-Mulberry Silkworm for the treatment of fever, as well as Professor Peng Jianzhong's clinical application experience and effective medical records, which could contribute to the development of clinical treatment of infectious fever in children.