Syndrome differentiation and treatment is the feature of Traditional Chinese Medicine. Professor LYU Renhe puts forward the syndrome method of "six diagnosis and treatment principles" including treatment according to the disease, treatment and differentiation according to the disease, syndrome differentiation according to the disease stage, treatment according to the symptom, syndrome differentiation according to the symptom, as well as combination of syndrome and disease differentiation according to the symptom, providing perfect ideas for clinical syndrome differentiation. Paeoniae Radix is a common Chinese medicine used by Professor LYU Renhe. Taking its application experience as the starting point, the academic thoughts of Professor LYU Renhe's "six diagnosis and treatment principles" were introduced in conjunction with themedical record system. Itmainly introduces the use of Sini Powder. Radix Paeoniae Rubra and Radix Paeoniae Alba are used to soften liver and nourish blood, promote blood circulation and remove blood stasis. Aiming at the syndrome of liver qi stagnation, in "Sandan Decoction", Danpi, Radix Salviae Miltiorrhizae, and Radix Paeoniae Rubra are used together, aiming at the pathogenesis of kidney disease "minimal symptom"; large doses of Radix Paeoniae Rubra and Radix Paeoniae Alba laxative symptomatic treatment experience in clinics.