Menopausal depression is a common and difficult disease that troubles women. Professor Yang Qunyu summed up according to clinical experience that this disease is mostly based on "liver and blood deficiency, spleen qi deficiency, kidney yang deficiency" and marked by qi stagnation, phlegm, dampness and blood stasis. In terms of treatment, the treatment methods include soothing liver and relieving depression, nourishing yin and moistening dryness, clearing heat and removing vexation, eliminating phlegm and regulating qi, warming and invigorating kidney yang. The treatment methods include Ganmai Dazao decoction, Xiaoyao decoction, simo decoction and Erxian decoction, which are applied flexibly and have better curative effects on this disease, reflecting the TCM clinical thinking of combining disease with syndrome and treating with syndrome, which is worthy of further studyand discussion.