Objective,2,To analyze the law of medicinals and discuss rules of clinical administration of Chinese medicinals and features of pattern differentiation and treatment in treatment of diabetic macular edema (DME).,Methods,2,The literature using TCM decoctions for treating DEM published at home and abroad were collected, analyzed and studied by applying modern computer data mining technology The core medicinals, core couplet medicinals and core medicinal combinations were analyzed, and the presicriptvons law was explored.,Results,2,A total of 54 articles were included in this study involving 99 kinds of medicinals with a total frequency of 540 counts. The top ten frequent single medicinals were ,Fuling, (Indian Bread,Poria,), Zexie, (Oriental Waterplantain Rhizome,Rhizoma Alismatis,),Huangqi, (Milkvetch Root,Radix Astragali seu Hedysari,),Danggui, (Chinese Angelica,Radix Angelicae Sinensis,),Chuanxiong, (Sichuan Lovage Rhizome,Rhizoma Ligustici Chuanxiong,),Zhuling, (Chuling,Polyporus,),Shengdihuang, (Unprocessed Rehmannia Root,Radix Rehmanniae Recens,),Baizhu, (White Atractylodes Rhizome,Rhizoma Atractylodis Macrocephalae,),Danshen, (Salvia Root,Radix Salviae Miltiorrhizae), and ,Cheqianzi, (Plantain Seed,Semen Plantaginis,). There were 19 types of TCM patterns, which were divided into 3 categories: phlegm-stasis obstruction, spleen deficiency and water retention, and qi-blood and yin-yang deficiency. The top four couplet medicinals according to association rules were ,Fuling-Huangqi,Fuling-Zexie,Chuanxiong-Danggui,Fuling-Danggui., The top three-medicinal combinations according to association rules were ,Fuling-Chuanxiong-Danggui, Zexie-Danggui-Fuling, and ,Fuling-Zexie-Huangqi., The top three four-medicinal combinations according to association rules were ,Zexie-Chuanxiong-Danggui-Fuling,Chuanxiong-Danggui,+,Huangqi+Fuling, and ,Zexie-Danggui-Huangqi-Fuling.,Conclusion,2,DME was treated mainly with medicinals with effects of tonifying qi and inducing dieresis, and with medicinals with effects of activating blood and enriching blood to supplement. The TCM pathogenesis of DME is qi-blood and yin-yang deficiency leading to internal water retention, binding of phlegm-stasis and obstruction of ocular collaterals over the time.