Professor Gao Hui has been engaged in TCM clinical work for 40 years and has considerable experience in TCM treatment of liver cancer. This article mainly analyzes and summarizes clinical experience of Professor Gao Hui in treating primary liver cancer, with a view to providing fellow doctors with new treatment ideas. Professor Gao Hui believes that the key to the pathogenesis of liver cancer lies in the deficiency and deficiency of the human body. The "wetness" and "phlegm" occupy an important mechanism in the pathogenesis of liver cancer. Treatment is strengthening spleen and stomach to consolidate middle jiao, promoting dampness and resolving phlegm to eliminate evil in cancer, emphasizing on the spleen and stomach play an important role in the occurrence and development of liver cancer. In view of the pathogenesis, modified Buyi Xiaozheng prescription has good efficacy, and it is worthy of clinical reference.