This article discusses Professor Mei Guo-qiang's experience of syndrome differentiation and treatment by Ningluo to rule out the hemorrhage, purple spots and intractable pain that caused by restless collaterals. It begins with the cause of collateral dysfunction, discusses its pathogenesis and treatment, and analyzes Professor MEI's experience of differentiation and treatment in combination with Professor MEI's case. The characteristics of differentiation and treatment can be summed up as Ningluo according to its origin, simplify the complicated situation; treatment depends on the severity of the disease; eliminates the pathogenic factor to prevent collaterals being stasis; if disease transforming into the collaterals for a long time, then making good use of insects and vine medicines. And briefly discourse his experience of differentiation and treatment about stopping bleeding, eliminating spots, relieving pain by Ningluo, so as to inherit and expand the dialectical thinking.