Huanglian Ejiao Decoction, firstly recorded in, Treatise on Febrile Diseases, could be used to treat heat-conversion syndrome of Shaoyin.It has been identified that, the indications of Huanglian Ejiao Decoction include:①in modern medicine, it can be used to treat insomnia, arrhythmia, oral ulcer, Xiali, blood syndrome and other diseases;②in terms of symptoms and signs, it is mainly used for restlessness, ritability, insomnia, extremely difficult to fall asleep, palpitation, atrial premature beat, ventricular premature beat and other arrhythmias, stomach distension and stuffiness, stomach pain, vomiting, abdominal pain, cramps, lower edge, constipation, blush, red lips, easy bleeding, red tongue, thin or no coating, dry tongue surface, or light red tongue, or dark red, thin white tongue coating, and rapid pulse.It has been also identified that, ①although the original statement of Huanglian Ejiao Decoction is very simple, it can not only be used according to irritability and insomnia;②tongue image is not the key to syndrome differentiation of this prescription;③the essence of Shaoyin syndrome is not completely heart kidney Yang deficiency, which is closest to shock in modern medicine, including septic shock, hypovolemic shock and cardiogenic shock;④the essential difference between Shaoyin cold and heat conversion syndrome of Shaoyin lies in the different types of shock, in which cardiogenic shock is the main cold type, while septic shock is the main heat shock;⑤heat-conversion syndrome of Shaoyin is more common in the late stage of septic shock, and part of it can be seen in the stage of heart failure combined with sympathetic activation;⑥Dioscoreae Rhizoma and Rehmanniae Radix are often used to replace egg yolk;⑦Huanglian Ejiao Decoction takes effect quickly and the course of treatment is short.