Chaige Jieji Decoction recorded in, Six Books of Exogenous Febrile Disease, could be used to treat exterior syndrome due to wind-cold and heat caused by stagnation.The indications of Chaige Jieji Decoction include acute exogenous febrile diseases, such as influenza, upper respiratory tract infection, nosocomial infection;symptoms and signs, such as headache, eye pain, orbital pain, dizziness;fever, cold and hot exchanges;dry mouth, thirst, cold drinks, bitter mouth, dry throat;dry nose, stuffy nose, runny nose;poor appetite, silent appetite;strong neck, stiff back;insomnia, difficulty in sleeping;cough and sputum;abdominal pain, limb twitching;slightly torrent pulse.Disease involving all three Yang channels is very common in acute exogenous febrile diseases;the pathogenesis of exogenous diseases is quite different between cases in South China and North China.Most of the exogenous diseases in North China involves all three Yang channels.Disease involving all three Yang channels is the core of the pathogenesis of Chaige Jieji Decoction syndrome, in which headache is the key indications.Chaige Jieji Decoction can not only treat exogenous diseases, but also treat nosocomial infections in critically ill patients during hospitalization.Although Chaige Jieji Decoction, Xiaochaihu-Maxing Shigan Decoction, and Xiaochaihu-Daqinglong Decoction could be used to treat disease involving all three Yang channels, there are differences in indicators among them.