Chinese classical formulas, firstly recorded in, Shanghan Zabing Lun, by Zhang Zhongjing in the Han dynasty, have been widely used by traditional Chinese medicine physicians for thousands of years due to its good compatibility, strict structures, significant clinical efficacy and less adverse effects.,Ephedra, associated prescriptions, widely used in the treatment of skin diseases, are famous representative prescriptions in Chinese classical formulas.The commonly used, Ephedra, associated prescriptions include Mahuang Lianqiao Chixiaodou decoction, Maxing Shigan decoction, Maxing Yigan decoction, Mahuang decoction, Mahuang Jiazhu decoction, Guizhi Mahuang Geban decoction, and Guizhi Eryue Biyi decoction.Skin allergy is an allergic reaction, manifested as erythema, papules, and itching.It has been identified that Guizhi Mahuang Geban decoction(1/2 Guizhi decoction+1/2 Mahuang decoction)is effective in dispersing wind and cold, relieving exterior syndrome and dredging the collaterals, so it can be used to treat skin allergy caused by pathogenic wind-cold.Guizhi Eryue Biyi decoction(1/4 Guizhi decoction+1/8 Yuebi decoction)is effective in dispersing wind and cold, relieving exterior syndrome and clearing heat, so it is mainly used for the syndrome of wind-cold tightening superficies and heat transformed from wind-cold.Additionally, Mahuang Lianqiao Chixiaodou decoction can relieve exterior syndrome, clear heat and remove dampness, mainly for the dampness and heat depression in the muscle surface.It is found that Guizhi Mahuang Geban decoction and Guizhi Eryue Biyi decoction have certain efficacy for skin allergies, while Mahuang Lianqiao Chixiaodou decoction has significant efficacy for urticaria, acute and chronic eczema, etc.It has been identified that if the conditions of, Ephedra, associated prescriptions are well mastered by traditional Chinese medicine physicians, they could be widely applied to treat exogenous diseases and miscellaneous diseases.