Professor WANG Shouchuan holds that the main pathogenesis of infantile malnutrition syndrome is the functional impairment of spleen and stomach which leads to dysfunction of transportation and transformation, loss of qi, blood and body fluid, and insufficiency of the source of generation and transformation as well. According to the severity and different stages of the condition, it is divided into 3 types including mild infantile malnutrition, mild infantile malnutrition with accumulation and dryness infantile malnutrition. Mild infantile malnutrition focuses on dysfunction of spleen, and thus Zisheng Wan(资生丸)is given to invigorate spleen and assist transportation. Mild infantile malnutrition with accumulation is generated and transformed by prolonged mild infantile malnutrition causing dysfunction of spleen resulting in retention of food and unsmooth circulation of qi and blood, which pertains to deficiency in the origin and excess in the manifestation, and thus Fei’er Wan(肥儿丸)combined with Xiaogan Lipi Tang(消疳理脾汤)is given to resolve food retention, regulating spleen, harmonizing stomach and spleen to clear away heat, by simultaneous use of dispersing and nourishing method. Dryness infantile malnutrition is generated and transformed by prolonged mild infantile malnutrition with accumulation causing spleen failure to transport cereal nutrient, loss of nourishment in viscera and dryout in qi and blood, and thus Bazhen Tang(八珍汤)is used selectively to invigorate qi, blood and induce appetite. Taking protecting the spleen and stomach as the basis for treating infantile malnutrition syndrome, professor WANG performs treatment based on syndrome differentiation in manifestation and origin as well as deficiency and excess according to the condition, whereby achieving marked clinical efficacy. Two proven cases are attached for verification.