Insomnia is caused by the disorder of the monarch and minister, and the main pathogenesis of insomnia is the disturbance of the ministerial fire that disturbs the operation of monarchic fire and Weiqi. Clinical treatment should be divided into four aspects: liver depression to transform fire, Shaoyang failure, liver blood deficiency, and liver and kidney yin deficiency. The combination of soothing liver, clearing liver, and nourishing liver should be used, and pay attention to the prevention and treatment of internal fire damaging yin. While investigating the etiology and pathogenesis, we must pay attention to the development of pathogens, prevent them in advance, and cutoff the progress of pathogens; The clinical treatment of insomnia takes a long time, and the pathological factors are often more complex. On the basis of qi stagnation, stagnation of fire and yin deficiency, blood stagnation and phlegm heat can be combined, clinical prescriptions must distinguish between primary and secondary contradictions, adhere to pathogenesis, and flexibly compose prescriptions; attention should be paid to enlighten patients to adjust their emotions to keep their spirits comfortable.