The main pathogenesis of reno-cardiac syndrome is both spleen and kidney deficiency, disharmony between heart and kidney, water dampness, turbid toxin and blood stasis. The treatment should be combined with disease and syndrome and treated by stages. In the stage of renal failure, it is mainly manifested as deficiency of both heart and spleen or deficiency of heart and kidney yin, and there is no obvious manifestation of water dampness and turbid toxin, so it is suggested that spleen should be invigorated and heart should be nourishing or kidney should be nourishing; in uremic stage, for the patients with deficiency of heart and kidney yang, deficiency of spleen and kidney qi(yang), and obvious water dampness, turbid toxin and blood stasis, we should treat them by strengthening spleen, warming kidney, strengthening heart, and promoting the circulation of blood; for the patients who have been treated with renal replacement therapy, the water dampness and turbid toxin has been removed by dialysis. In the early stage, there are two injuries of qi and yin, and the blood stasis is left inside, so the method of benefiting qi, nourishing yin and activating blood circulation can be used; in the late stage, the deficiency of both yin and yang and the internal obstruction of blood stasis should be treated by the combination of tonifying yin and yang.