The pathogenesis of refractory fever is complex, and tumor fever is representative in refractory fever. Professor Shi Zaixiang believes that the key to the use of classical formulas in the treatment of refractory fever lies in accurate syndrome differentiation. In the clinical practice, we should base on the concept of holism and clarify the relationship between evils and healthy ,qi,. When prescribing, we should abide by the pathogenesis and the correspondence between formulas and syndromes, not only follow the concept of holism of TCM and the basic characteristics of syndrome differentiation and treatment, but also emphasize more accurate syndrome differentiation and individualized treatment. Professor Shi has established the method of removing fever by clearing three-yang, the method of dispersing fever by banking up earth to benefit metal, and the method of conducting fever by edema to remove blood stasis. Pueraria Decoction plus Shigao (,Gypsum Fibrosum,) combined with Major Bupleurum Decoction, Licorice and Rhizoma Zingiberis Decoction combined with Ephedra and Apricot Kernel and Gypsum and Licorice Decoction, Peach Kernel ,Qi,-Guiding Decoction for edema are often used respectively in the above methods to treat refractory fever.