According to the characteristics of headache during menstruation, Professor Luo Zhi-juan adopts "Master Guiluo's three-way classification", that is, according to the patients' syndrome type, different stages of disease development and menstrual cycle, "syndrome classification", "stage classification", "cycle classification" are used to select proper formulas and medicinals. "Syndrome classification" means that the local syndrome differentiation is used to determine the pathological viscera and meridians, and the overall syndrome differentiation is used to determine deficiency, excess, cold and heat of headache. There are two basic pathogenesis of headache during menstruation, one is imbalance of ,qi, and blood, the other is ,qi, counterflow. The combination of the two factors causes disease. For those with excess syndrome,qi, and blood circulation should be promoted to relieve pain; for those with deficiency syndrome,qi, and blood should be nourished to relieve pain. No matter what syndrome, calming throughfare vessel should be paid attention to. The treatment should start from the liver, spleen and kidney, combined with the syndrome type, by nourishing kidney and strengthening throughfare vessel, or calming liver and lower conterflow of qi, or invigorating spleen and harmonizing middle energizer. "Stage classification" means that headache during menstruation can be divided into pain stop stage and pain stage. For headache at pain stop stage, the treatment should focus on removing the root cause. According to different syndrome types, either replenishing ,qi, and nourish blood, or nourishing yin and subduing yang, or promoting blood circulation and removing blood stasis, or drying dampness and resolving phlegm can be used. There is no need for the medicinals for dredging meridians to stop pain. For headache at pain stage, Tea-Mix and Chuanxiong Powder combined with Tianma (Rhizoma Gastrodiae) and Yanhusuo (Rhizoma Corydalis) is often used to relieve pain by treating the secondary aspect. "Cycle classification" means that headache during menstruation can be divided into three periods. During menstruation, removing blood stasis is the key. After menstruation, nourishing yin and blood to promote yang is the key. Before menstruation, nourishing kidney to strengthen yang is the most important. The results of three-way classification should be combined with each other rather than being biased. The syndrome differentiation should be added and subtracted according to various syndrome types in different circles and stages.