To analyze the medication rules of dampness-dispelling formula by combining with the medication characteristics of famous dampness-dispelling formula in past dynasties. Its treatment focuses on regulating the function of spleen, lung and kidney and should be combined with spleen-invigorating medicine to control dampness by cultivating the earth; combined with lung-diffusing medicine to regulate the water passage; combined with kidney-warming medicine to assist yang, transform qi and drain dampness in order to normalize the fluid circulation. Syndrome differentiation should be used in the clinical diagnosis and treatment. Those who are mainly deficient, invigorating spleen, lifting yang or nourishing yin and dispelling dampness, or warming kidneys to assist transportation and transformation should be used. Medicine for promoting urination, invigorating blood and dissolving stasis, clearing heat should be used for excessive pathogens. The ways of clearing and draining should be used for damp-heat, warming and drying for damp-cold, dispersing for external dampness, percolating and resolving dampness with bland and fragrant medicinals for internal dampness. Clinical treatment should be based on the specific syndromes and focused on syndrome differentiation and treatment, medication according to syndromes so as to achieve the satisfied efficacy.