The paper introduced professor Gu Kuixing's experience in diagnosing and treating esophagus cancer. It was regarded that esophagus cancer was a symptom of root-deficiency and branch-excess. Deficiency of healthy qi and dysfunction of zang-fu organs were the pathological base while binding of phlegm-stasis and accumulation of cancer toxin were the keypoints. As for the treatment, it was highlighted that regulating midddle-jiao of spleen and stomach, combined with dissolving phlegm and removing stasis, softening hardness and dissipating masses, and clearing heat and resolving toxins. In addition, differention of disease and symptoms should be combined and in different stages, targeted diagnosis and treatment should be applied and prescription should be in accordance with three categories of etiologic factors.