Professor RUAN Shiwei is a famous traditional Chinese medicine in Fujian Province. He has been engaged in clinical practice for many years and is good at treating kidney diseases with tripletdrugs. Chronic kidney disease is often caused by wind-heat invading lung. The heat in lung can invade the kidney, damaging blood vessels and kidney collaterals, and then leading to blood in urine. If the upper Jiao disease is not cured, it can pass on to the lower Jiao, and the kidney is in the lower Jiao. Therefore, if there is damp-heat in the upper Jiao, the evil of damp-heat will invade the kidney. The heat is accumulated in the lower Jiao for a long timeand the impurities in the urine are formed as "Shilin". Tripletdrugsare originated from ,Suwen,·,Zhizhenyao,. It makes use of the basic characteristics of traditional Chinese medicine to reasonably and skillfully combine the three Chinese drugs, which is like a tripod with each other as horns. Professor RUAN Shiwei uses a number of prescriptions composed of tripletdrugs for diagnosis and treatment according to the syndrome differentiation, the overall state and different body states of patients with kidney disease, the theory of dynamic pathological changes of macro and micro as well as changes of large system and subsystem. Professor YU Shixuan often uses Shanzhuyu (Cornus), Shudi (Rehmannia glutinosa), Shanyao (Chinese yam); Pipaye (Loquat leaves), Shegan (Belamcanda chinensis), Yujin (Turmeric); Ganjiang (dried ginger), Wuweizi (Schisandra), Xixin (Asarum); Lianqiao (Forsythia), Bohe (Mentha haplocalyx), Zhizi (Gardenia); Huangbai (Phellodendron), Zhimu (Anemarrhena), Guizhi (Cassia twig); Jinyingzi (Rosa laevigata), Qianshi (Euryale ferox), Fupenzi (raspberries); Shangjicai (Capsella bursa-pastoris), Guijianyu (Euonymus alatus), Qiancaotan (madder charcoal); Jinqiancao (Lysimachia), Haijinsha (Lygodium japonicum), Jineijin (Gallus gallus domesticu); Shengdi (Rehmannia glutinosa), Qinjiao (Gentiana), Xixiancao (Siegesbeckia); Heye (lotus leaf), Huangqin (scutellaria), Dahuang (rhubarb); Bohe (Mentha haplocalyx), Huashi (talc), Gancao (Licorice), and other combination to nourish lung and kidney, cool blood to stop bleeding, invigorate blood and resolve phlegm, invigoratekidney and eliminate dampness. The curative effect is outstanding. This article discussed the composition, efficacy, compatibility points, and adaptations of the 11 groups of triplet drugs commonly-used by Professor RUAN in clinical diagnosis, and summarized Professor RUAN's experience on treating renal diseases.