In the early stage of diabetes, most of the patients have the habit of eating too much food with the greasy, sweet and surfeit flavours, leading to the syndrome of gastrointestinal stagnated heat in the spleen and stomach, which is mostly manifested as the syndrome of excessive heat in the middle jiao. Therefore, Academician Tong Xiaolin believes that the core pathogenesis of diabetes in its early and middle stages is the flatulence and endogenous heat, mainly in a heat state, with the gastrointestinal excessive heat as its chief syndrome, with dry mouth, bitter taste in mouth, halitosis and dry stool as its symptom targets, and with the increase in blood glucose as its index target, with purging heat and relieving flatulence, promoting qi-flowing and activating pancreas as its primary treatment method. He makes a minor experiential prescription Tongcui Yin for the treatment of diabetes mellitus, which is composed of raw rhubarb root and rhizome, golden thread and areca seed. Simple as the minor prescription is, it is rather effective in regulating the disease state and target simultaneously. In the prescription, raw rhubarb root and rhizome is the main medicine for purging heat, removing stagnation and clearing the organs, with a common clinical dosage of 3-15 g. Golden thread, with the most bitter taste and cold nature, is good at clearing the stagnated heat in the middle jiao, and is also an effective hypoglycemic target drug, with a common clinical dosage of 15-30 g. Areca seed can promote qi movement and relieve food retention, with a common clinical dosage of 6-15 g.