Deficiency of the spleen-qi, insufficient functions of transporting, absorbing, constraint and ascend are the core pathogenesis of many diseases such as distention and fullness, constipation, diarrhea, obesity, diabetes, bleeding, and organ prolapse. According to academician TONG Xiaolin, we should seize the core pathogenesis through precise diagnosis and flexibly medicate according to the symptoms and severity of the disease. Radix Astragali, Ginseng, Atractylodis Macrocephalae Rhizoma are commonly used as the basic three prescriptionin in invigorating spleen and replenishing qi. Radix Astragali is good for nourishing qi, Atractylodis Macrocephalae Rhizoma is beneficial to strengthening the spleen, and Ginseng Radix ET Rhizoma to replenish vitality, the compatibility of the three drugs, together to invigorate spleen and replenish qi, strengthen the immuntiy and control the blood circulation, and prevent organ prolapse. The common dosage of Radix Astragali is 15-60 g, Ginseng Radix ET Rhizoma is 3-15 g, and Atractylodis Macrocephalae Rhizoma is 9-60 g.