Buzhong Yiqi decoction, mainly composed of Astragalus membranaceus dried tangerine peel and Fried Atractylodes macrocephala, is an effective prescription for clinical differentiation and treatment of Brittle diabetes deficiency of Zhongqi syndrome by Professor TONG Xiaolin. Fatigue and weak pulse are the important factors to choose it. In this decoction, Astragalus membranaceus can tonify the middle qi and promote yang to strengthen the exterior by using 30-120 g; Fried Atractylodes macrocephala for invigorating qi and spleen by using 9-30 g;The Pericarpium Citri Reticulatae can regulate qi and stomach, so that the herbs can be used to replenish but not stagnate by using 9-15 g. It can also be used in patients with fragile diabetes whose main manifestations are fatigue and weakness of the body, light tongue and pulse deficiency, as well as visceral ptosis, chronic gastroenteritis and myasthenia gravis. At the same time, a large number of clinical studies and evidence-based medicine evidence show that the above three single drugs and their compound compounds have significant two-way blood glucose regulation effect, which is the first-line drug for brittle diabetes patients to control blood glucose by means of traditional Chinese medicine.