Massa Medicata Fermentata, Rhizoma Pinelliae Fermentata and Fermentum Rubrum are commonly used herbs in the treatment of hyperlipidemia by Professor TONG Xiaolin. The clinical diagnosis and treatment of this disease are spleen deficiency and the accumulation of solid evil, and both tip and root should be taken care of.During treatment, acrid opening and bitter downbearing, turbid and lipid descending, balanced regulation of cold and heat are the rules. In terms of clinical dosage, 9-15 g of Massa Medicata Fermentata is commonly used to invigorate the spleen and stomach, and to regulate the middle-jiao; 9-15 g of Rhizoma Pinelliae Fermentata is commonly used to relieve diarrhea, dry dampness and resolve phlegm, and assist in the elimination of pathological products; Fermentum Rubrum is used to lower blood lipids, invigorate the spleen and dry dampness and reduce turbidity, the clinical dosage range is 3-15 g. Modern pharmacological research shows that the above three herbs can promote gastrointestinal motility, regulate intestinal gutmicrobiota, reduce total cholesterol, triglycerides, and low-density cholesterol content, providing modern scientific basis for the treatment of hyperlipidemia.