Hyperthyroidism is a common clinical disease, and traditional Chinese medicine has certain advantages in improving patients’ clinical symptoms, thyroid function and so on. Academician TONG Xiaolin believes that the core pathogenesis of hyperthyroidism is liver fire exuberance and blockade of phlegm-turbidity. The principle of treatment is the bitter cold and clearing heat, and astringent, and the treatment is to clear the liver, detoxify and resolve masses, collect the liver and protect the liver, supplemented by resolving static blood, and detumescence. The three small prescriptions composed of Spica Prunellae, Rhizoma Dioscoreae Bulbiferae, Fructus Schisandrae Chinensis are the drugs for the treatment of the morbid target, one is to clear the liver fire, the second is to resolve static blood, and detumescence, and the third is to collect the liver and protect the liver. The commonly used clinical doses of this prescription are Prunella vulgaris 30-120 g, Rhizoma Dioscoreae Bulbiferae 9-15 g, Schisandra 9-30 g.