Depression is one of the common incurable diseases in the clinic. Western medicine treatment is mainly symptomatic treatment. The curative effect is significant in a short period of time, but it is often accompanied by serious side effects. Professor TONG Xiaolin took a different approach and proposed that the state of depression should be treated from the kidney, and summarized the pathogenesis of the disease as "the deficiency of the yang, the vitality will be dim and wilt will occur". The basic rule of treatment is strengthening the yang and dispelling the haze. "Tongshi Guangming Pill" is often used in clinical practice. "Tongshi Guangming Pill" is composed of Epimedium Herb, Ginseng and Prepared Common Monkshood Branched Root. It has the effects of nourishing the kidney and reinforcing the fire as well as strengthening the yang and dispelling the haze to treat the sun deficiency depression state with remarkable results and can provide safe and effective treatment for patients with clinical depression state.