Frequent urination at night seriously affects the life and sleep quality of patients, it can increase the risk of sudden death in the elderly at night at the same time. It is of great significance to improve the symptoms of nocturia.Professor TONG Xiaolin believes that Enuresis is a predictive disease of early renal arteriosclerosis for the elderly and diabetic patients with poor blood glucose control. The basic treatment principles are tonifying kidney to Suoquan and promoting blood circulation for removing obstruction in collaterals. Professor TONG Xiaolin often used Astragalus membranaceus, asiatic cornelian cherry fruit and leech as the basis of clinical compatibility for the treatment of nocturia. In the formula, Astragalus membranaceus benefiting qi and Guse, Cornus officinalis can nourish kidney yin, it can also enhance the ability of other drugs to collect urine. Leech can dredge renal collateral, resist the decrease of blood flow caused by early renal arteriosclerosis and increase renal blood flow. It is one of the commonly used drugs for xueluo. It can also remove blood stasis and dredge collateral, and prevent turbid poison from damaging collaterals.The commonly used dose of Astragalus is 30-90 g, that of cornus is 9-30 g, and that of leech is 3-6 g.