Intractable headache is one of the common clinical complications. Traditional Chinese medicine has achieved a more satisfactory clinical effect in the treatment of this disease. Professor TONG Xiaolin believes that luomai butong is the direct cause of this disease, similar to the microcirculatory disorders proposed by Western medicine. Among the pathogenic factors of the disease, feng, tan and yu are particularly important. Long-term disease enters the collaterals, only worm medicine can entering the position, and 1 to 1.5 g powder of Centipede, Scorpion and stiffsilkworm are usually used by him. The main functions are as follows: the first is to dispel feng and induce all kinds of drugs to go up; the second is to improve blood circulation and disperse stasis; the third is to dredge collaterals and relieve pain. The prescription can obviously relieve pain and significantly reduce the number of headache attacks, the degree of headache. It has good clinical efficacy and safety in the treatment of intractable headache with long course of disease.