Nutrient qi and body fl uid are important components of blood. Food essence is the most basic substance of metaplastic blood. The formation of blood is closely related to spleen. If the function of spleen governing the transportation and transformation is normal, the essence and blood are metabolized, and qi and blood are abundant; if the spleen is not healthy, qi and blood are lack of source, and the diseases such as de fi ciency, bleeding, blood de fi ciency, internal injury and fever may occur. Based on this theory, classical formula Guipi Decoction is widely used in diseases of multiple systems. Guipi Decoction is fi rst published in Jishengfang, supplemented by Xue Ji, and it has been used until now. It has the function of invigorating qi and blood, strengthening spleen and nourishing heart. Professor Sun is a famous Chinese medicine practitioner engaged in the treatment of blood diseases for more than 50 years. He inherits the traditional Chinese medicine thought and pays attention to the practical application of classical prescriptions. He used Guipi Decoction to treat various diseases, especially in blood diseases, and achieved good treatment results.