Coronavirus disease-2019 (COVID-19) outbreaks were spreading rapidly around the world in early 2020.This disease is within the category of"damp epidemic"and"damp toxin epidemic"in traditional Chinese medicine, with lung and spleen as the lesion focuses, while dampness and toxin as especially prominent properties.Through clinical observation, we found that dampness would often transform into damp heat during the development and evolution of the disease, and the"triple energizer"treatment was an important therapeutic method, eliminating pathogens through purgation and diuresis: for those with damp-heat accumulation toxin diffused to the triple energizer, we could use Ganlu Xiaodudan as primary prescription, which can spread the upper part, smooth the middle part and infiltrate the lower part, so as to provide a way out for the pathogenic factors and regulate Qi movement.For those with damp-heat in Shaoyang channel, we could use Haoqin Qingdantang to clear heat and promote diuresis, harmonize Shaoyang, eliminate damp-heat and epidemic pathogenic factor.For those with pathogen hidden in membrane source dampness trapping and hidden heat, we could use Dayuanyin to eliminate pathogens between interior and exterior parts, and regulate Qi movement.At the same time we shared three typical cases treated in Wuhan, and conducted an in-depth analysis in this study.Clinically, the method of elimination of pathogens through purgation and diuresis is mainly used in the early and middle stage of this disease.When the disease is still located in Qi system, it also can be applied to mild, ordinary patients and severe patients that have accurate syndrome differentiation.In such cases, it can effectively improve symptoms, reduce pathogenic toxin, truncate and reverse the course of disease, give way to pathogen, and avoid disease aggravating.