The clinical experience of Professor QIU He-Ming in treating idiopathic thrombocytopenic purpura (ITP) was Summarized.Professor QIU He-Ming believes that the main pathogenesis of ITP is characterized by deficiency in the origin and excess in the superficiality, the deficiency in the origin is manifested as the insufficiency of five zang organs, and the excess in the superficiality is manifested as the fire-heat intensity.Following the thoughts for the treatment of blood syndrome recorded in Treatise on Blood Syndromes, a book written by TANG Rong-Chuan in Qing dynasty, Professor QIU He-Ming adopted the tetrad-therapy of stopping bleeding, eliminating blood stasis, calming blood, and nourishing blood to treat ITP.During the treatment of ITP, therapy of stopping bleeding should be used firstly and can be achieved by astringency-inducing drugs and cooling blood, eliminating blood stasis should be used based on etiological differentiation and the herbs for activating blood should be avoided, calming blood is used for eleminating the pathogenic factors and herbs for tranquilizing heart, liver and lung can be utilized, and nourishing blood is used for tonifying five zang organs, in particular for tonifying liver, spleen and kidney.For the treatment of IPT, Professor QIU He-Ming has estalished a prescription of Ziyin Zhixue Recipe to stop bleeding, eliminate blood stasis, calm blood, and nourish blood, and the prescription is mainly composed of the herbs of Radix Rehmanniae Preparata or Radix Rehmanniae, Rhizoma Dioscoreae, Fructus Corni, Herba Agrimoniae, Radix Melastomae, Herba Cirsii, Fructus Forsythiae, Flos Schizonepetae, and Radix Glycirrhizae.The modification of Ziyin Zhixue Recipe based on symptoms is effective on relieving the clinical symptoms, improving the platelet level, and can make the patients be gradually free from steroid dependence.