Professor XIA Guicheng holds that premature ovarian insufficiency(POI)is owing to the dysfunction of heart-kidney-uterus axis and disharmony between heart and kidney.The cause of POI is deficiency of kidney-,yin,gui,-water(癸水)premature depletion, while it is closely related to heart.POI onset is mostly due to patients'chronic mental stress leading to disquieted heart-mind, flaring up of heart fire, heart-blood ,ying-yin, hidden consuming.A long time, kidney-,yin, is more and more deficient, which cannot produce essence, transform marrow and nourish heart-mind.A vicious cycle leads to POI.Menstrual cycle rhythm regulation method should be combined, treating from heart and kidney.The first and important is to treat heart, clearing heart-fire, nourishing heart-,yin, to lower heart-fire first. “Heart tranquillization“ could bring “kidney enrichment“ .Intercourse between heart and kidney makes premature depletion ,tiangui,(天癸)renascence, re-establish ,Yin-Yang, balance of heart-kidney-uterus axis and restore normal reproductive endocrine, with normal menstruation, to treat the root.