Sexual intercourse in dream is also called sexual dream. This disease is not common in clinical gynecology. The ancients believed that the disease was mostly caused by blood loss and sperm loss, weak viscera, and loss of mind. If sexual intercourse in dream occurs during pregnancy, it is likely to cause fetal irritability, even abortion, and miscarriage. Professor WANG Xiuyun treated the disease clinically, and believed that the pathogenesis of the disease was insufficient kidney Yin, heart-kidney imbalance, and lack of fire disturbed the impulse and uterus, causing fetal irritability. Sancai Fengsui Pill (三才封髓丹) is used for symptoms of deficiency of fire and inflammation, loss of essence in dreams, it has the functions of reducing fire and strengthening Yin, consolidating essence and sealing marrow. Professor WANG Xiuyun's clinical application of Sancai Fengsui Pill in the treatment of fetal irritability caused by sexual intercourse in dream, because it has the effect of nourishing kidney and Yin, nourishing heart and calming nerves, and strengthening and relieving fetus. Balance between Yin and Yang, fire and water help each other, sexual intercourse in dream are stopped, and the fetus is in peace.