Professor BAI Changchuan has been engaged in TCM clinical work for more than 50 years. He is a national famous TCM doctor, the winner of the National Outstanding Contribution Award for TCM, and the instructor of inheriting the academic experience of the third, fourth and sixth groups of TCM experts. Professor BAI has rich clinical experience and unique characteristics in syndrome differentiation and treatment. In clinical diagnosis and treatment, he takes drugs according to Zang-Fu organs and channels, Qi and blood, cold and warm, meridians and drug properties. In particular, he attaches great importance to the new use of ancient prescriptions, explores the clinical function and compatibility of new drugs, and considers the dose and efficacy in toxicity application. In addition, academic ideas such as the unification of spleen and stomach caused by stagnation, cold and warm, the localization of triple energizer and Zang-Fu organs, the qualitative analysis of Qi and blood, and the four-stage deficiency and reality set have been gradually formed in academic thoughts, and the classical clinical pathway of TCM has been established, which has achieved good results in the diagnosis and treatment of common diseases and complex diseases. This paper summarized the characteristics of Professor BAI′s clinical prescription selection, taking the seven methods of strengthening spleen, three Jiao for treating cough, four rules of treating fever, the syndrome differentiation system of "three parties" and "three syndromes" , and the system of quoting scriptures in anatomical regions as examples, in order to provide new ideas for clinical practice, academic inheritance of famous traditional Chinese medicine, inheritance and innovation of TCM theory and application.