Objective,2,To analyze Professor WANG Zhenchang's clinical experience on treating liver cirrhosis.,Methods,2,Professor WANG Zhenchang's clinical experience in the treatment of liver cirrhosis was discussed from the aspects of etiology and pathogenesis, rule of medication, etc. The medication rule of Rougan Huaxian Granules (柔肝化纤颗粒) in the treatment of liver cirrhosis was summarized, and a typical case was listed.,Results,2,Professor WANG Zhenchang believed that deficiency, dampness and blood stasis ran through the whole course of liver cirrhosis, and the three coexisted and caused each other. The etiology of liver cirrhosis was mainly due to liver and kidney Yin deficiency, loss of liver support, liver failing to disperse and drain, endogenous or exogenous invasion of dampness and blood stasis, which was associated with liver due to deficiency. Treatment should be based on the principle of nourishing liver and kidney, dispelling blood stasis and eliminating dampness. Professor WANG's treatment of liver diseases follows the concepts that "liver disease would transform into spleen, and spleen should be strengthened first" and "liver and kidney are homologous" . On this basis, Professor WANG created Rougan Huaxian Granules, a clinical prescription for the treatment of liver cirrhosis, and confirmed that a good clinical effect can be obtained by modified Rougan Huaxian Granules according to syndrome differentiation.,Conclusion,2,Based on differentiation of symptoms and signs and according to different pathogenesis such as dampness, blood stasis and deficiency, Professor WANG Zhenchang uses Rougan Huaxian Granules as the main prescription for liver cirrhosis which can effectively control the disease development of liver cirrhosis patients, worthy of reference and study.