Professor LYU Wenliang believes that the pathogenesis of chronic viral hepatitis B is nothing more than three pathological factors, which are toxin, blood stasis and deficiency. Therefore, the treatment in clinic is often based on this. The first is to attach importance to strengthening the vital energy, and is adapt at using traditional Chinese medicines such as Huangqi (Radix Astragali), Baizhu (Radix Atractylodis Macrocephalae), Shanyao (Yam), Baishao (Radix Paeoniae Alba), Shengdihuang (Radix Rehmanniae), Nuzhenzi (Fructus Ligustri Lucidum) and Mohanlian (Eclipta alba), to invigorate spleen and Qi and nourish liver and kidney, in order to control the deficiency of liver, spleen and kidney. The second is to pay attention to attacking the toxin and relieving the stagnation, and is adapt at using traditional Chinese medicines such as Jiaoshanzha (Crataegi Fructus), Jiaoshenqu (Massa Medicata Fermentata), Jiaomaiya (Hordei Fructus Germinatus), Huangqin (Radix Scutellariae), Huanglian (Rhizoma Coptidis), Huangbai (Cortex Phellodendri), Yinchen (Artemisia capillaris) and Xiongdan (bear bile) powder, to clear away heat and dampness, eliminate phlegm and clear away turbidity, eliminate food stagnation and purge the toxin. The third is to resolve blood stasis and eliminate the mass, and is adapt at using Shanzha (Crataegi Fructus), Chuanxiong (Chuanxiong Rhizoma), Ruxiang (Olibanum), Moyao (Myrrha), Yujin (Curcumae Radix), Yimucao (Leonuri Herba), Yanhusuo (Corydalis Rhizoma), Hongjingtian (Rhodiolae Crenulatae Radix Et Rhizoma), Sanleng (Sparganii Rhizoma), Ezhu (Curcumae Rhizoma), Shuizhi (Hirudo) and Wangbuliuxing (Vaccariae Semen), to activate blood circulation and dredge collaterals and soften and disperse the mass. The righteousness is restored, and then the body is as usual. The evil toxin is removed, and then the body has no worries of infestation. The blood stasis is clear, and then the body has no closed disturbance. Therefore, this article summarized the characteristics of Professor LYU Wenliang's treatment of chronic viral hepatitis B from toxin, blood stasis and deficiency and briefly described his academic experience.