Professor GAO consideres the main manifestations is that the lower limbs are too weak and impotent to stand upright and lumbar spine is weak or aching and limp according to the record in Plain Questions. It is said kidney is the organ of water, for now the water cannot prevail against fire and so the bones are withered, and the marrow empty. So the foot can not support the body, leading to bone impotence. The pathogenesis is mainly kidney Yin deficiency, producing internal heat, involving deficiency of spleen and stomach and the fire due to deficency or pathological products of the Zang-fu organs, and it also can be combined with blood stasis. Clinically, it is divided into three syndrome types, kidney deficiency, spleen and stomach deficiency, blood stasis. The characteristics of medication is nourishing kidney and strengthening bone, clearing deficiency heat at the same time and harmonizing spleen and stomach as a supplement to stretching tendon and nourishing bone, attaching great importance to promoting blood circulation to remove stasis and regulate veins, identifying the lesion of Zang-fu organs and paying attention to the application of heat-clearing method. When treating impotence, professor GAO examins the causes based on syndrome differentiation.