Through the analysis of typical cases, the disease was identified as Yangming-Shaoyang concomitant disease, treating with Dachaihu Decoction for purging the heat mass. When it becomes Yangming-Shaoyang concomitant disease, treating with Banxia Xiexin Decoction for regulating cold and heat. The disease was identified as Jueyin disease and was cured by the dissolution of cold and the decoction of dried ginger and cassia twig. The disease was identified as Shaoyin-Taiyin concomitant disease, and was cured by Zhenwu Decoction for warming Yang and promoting urine. Professor HUANG Shi from medical record discussed the development process and mechanism of six-channel differentiation, distinguished the six channels first and then sydnromes and prescriptions. The prescription was made according to the pulse condition, paying attention to guidance of sphygmology. It combines disease and syndrome differentiation and pays attention to local and overall combination to provide some experience for the treatment of gastroesophageal reflux disease.