Professor SI Guomin, the director of Department of Traditional Chinese Medicine, Shangdong Province-owned Hospital, has been working in clinic for more than 30 years.The third batch of the national traditional Chinese medicine expert academic experience in succession to the academic successor.The superb medical skill and noble medical ethics to attract all over the country to Jinan for treatment of patients with difficult miscellaneous diseases.More than 80% of the prescriptions use Astragalus and the dosage is larger, commonly used 30-40 g. Use of Astragalus also can relieve Qi deficiency symptoms of patients and the clinical curative effect is satisfactory.In this paper, the author summarizes the experience of the clinical application of Astragalus.