Objective,:,2,To explore the connotation and clinical guidance of the "five spirits theory of traditional Chinese medicine" studied by professor TENG Jing.,Methods,:,2,By collecting and organizing professor TENG Jing's treatment of mania, combined with the madness of the etiology and pathogenesis, from the physiology and pathology of the five spirits, it elucidated the pathogenesis of five spirits disorder madness from the pathogenesis evaluation of disease and establishing therapeutic targets, to guide the clinical syndrome and build syndrome differentiation system.,Results,:,2,The treatment of mania syndrome should be based on the five spirits, combined with the etiology and pathogenesis, and set up a system for the diagnosis and treatment of the five spirits from the mental and psychological level.,Conclusion,:,2,Professor TENG Jing's theory of the five spirits of TCM provides a new theoretical method for the diagnosis and treatment of mania, and opens up a new way of clinical diagnosis and treatment.