With the development of society, the potential pressure of life, work and other aspects makes people stay in a state of anxiety and depression for a long period. As China has gradually entered the aging society, the number of women stepping in menopause is increasing year by year. Faced with these negative emotions, menopausal women are more difficult to make through the negative emotions, so that the number of menopausal women suffering from perimenopausal syndromes (PMS) is growing continually, and onset age has been younger than before. A number of menopausal women have varying degrees and various severity syndromes of PMS, which could be affected by various factors, such as individual differences, complexity of social environment, particularity of personality and other factors. When the problem gets serious, it might affect their daily lives. Besides, its various symptoms could result in the obvious differences of the treatment, efficacy and prognosis. Professor LAI proposes three points for PMS's etiology pathogenesis as well as the treatment therapy: ①Treat the exterior and then the five Zang-organs. ②Strengthen Chong and Ren meridians becasue Ren meridian and Governor meridian can irrigate Zang-fu organs. ③Acupuncture combined with medicine to dredge the Governor meridian and guide the Qi return to the origin. Applying the Tongyuan therapy to treat PMS has a significant effect.