Summary of case history,　A male patient complained of overall weakness, inability to walk, and difficulty swallowing for over a year. A year ago, he was diagnosed with primary systemic amyloidosis at a Western Hospital due to fatigue, enlarged tongue, and painful swallowing difficulties. After pathological examination, he was diagnosed with primary systemic amyloidosis. And receive hormone and other medication treatment. After seeking treatment in multiple hospitals across the country, there was no improvement and the condition was severe. Recently, the patient's overall fatigue and difficulty swallowing have worsened. In order to seek further diagnosis and treatment, the patient has come to our hospital for treatment. At this time, the patient's general condition is poor, and they are carried into the consultation room, extremely weak, unable to walk, with a dull complexion, indifferent expression, difficulty swallowing and speaking, and can only eat a small amount of liquid food. Giant tongue, unable to fully extend, with teeth marks, thick and greasy coating, and thin and weak veins. A history of subtotal gastrectomy for 2 years. Denying the history of Ye You; Deny any history of drug or food allergies. Deny family genetic history.,TCM diagnosis,　bi syndrome - tongue bi (syndrome of phlegm and blood stagnation, qi and blood deficiency),Western medicine diagnosis,　primary systemic amyloidosis,Therapeutic methods,　Treatment principles: resolving phlegm and dispersing nodules, removing blood stasis and unblocking collaterals, supplementing qi and nourishing yin. Prescription: 15g corrugated seeds (first decocted), 15g platycodon grandiflorum, 10g roasted licorice, 25g turtle shell (first decocted), 20g prunella vulgaris, 30g oyster (first decocted), 30g coix seed, 20g astragalus membranaceus, 15g red peony, 30g ophiopogon japonicus, 20g kudzu root, 30g poria cocos, 15g fried atractylodes macrocephala, 30g codonopsis pilosula, 20g scallion seed, 30g yam, 20g white thatch root, 25g centella asiatica, 20g salvia miltiorrhiza, 10g white sorghum powder (taken orally), 40g pangolongrass, 6g Jia Zhu (ground into powder and swallowed). 7 pairs in total, boiled in water, 1 pair per day, 300ml divided into 2 servings in the morning and evening,Clinical outcomes,　After the second treatment, the patient's mental state improved compared to before. After adjusting the medication, he continued to take 7 doses. After the third treatment, the patient's mental and physical strength recovered compared to before. He continued to take 40 doses. After the fourth treatment, the patient's body was stronger than before, and they were able to assist in walking. The difficulty in swallowing significantly improved, and they were able to eat solid food with itchy skin. After adjusting the medication, he continued to take 42 doses. After the fifth treatment, the patient's skin itching improved, and they still felt tired, nauseous, with a large tongue and weak pulse. After adjusting the medication, he continued to take 14 doses. After the sixth treatment, the patient's condition improved, without the need for assistance, and was able to walk on their own, coughing and coughing phlegm. After adjusting the medication, he continued to take 7 doses. After the seventh treatment, the patient's cough and sputum were relieved, the precordial area was uncomfortable, and sleep was poor. After adjusting the medication, he continued to take 14 doses. After the eighth treatment, the patient's symptoms improved. After adjusting the medication, he continued to take 30 doses. After a follow-up of six months, the patient's condition was stable and in good condition.