王晋平从湿温论治危重型结核性脑膜脑炎经验
WANG Jinping's Experience in Treating Critical Tuberculous Meningioencephalitis from Damp-warm Syndrome
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1.广西中医药大学第一附属医院,南宁 530023
2.广西中医药大学,南宁 530001
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王晋平, 何草, 谢荣鑫. 王晋平从湿温论治危重型结核性脑膜脑炎经验[DB/OL].(2023-10-28)[2023-11-05].http://cccl-tcm.cacm.org.cn/thesisDetails?columnId=43200280&Fpath=home&index=0
WANG Jinping, HE Cao, XIE Rongxin. WANG Jinping's Experience in Treating Critical Tuberculous Meningioencephalitis from Damp-warm Syndrome[DB/OL].(2023-10-28)[2023-11-05].http://cccl-tcm.cacm.org.cn/thesisDetails?columnId=43200280&Fpath=home&index=0
王晋平, 何草, 谢荣鑫. 王晋平从湿温论治危重型结核性脑膜脑炎经验[DB/OL].(2023-10-28)[2023-11-05].http://cccl-tcm.cacm.org.cn/thesisDetails?columnId=43200280&Fpath=home&index=0 DOI:
WANG Jinping, HE Cao, XIE Rongxin. WANG Jinping's Experience in Treating Critical Tuberculous Meningioencephalitis from Damp-warm Syndrome[DB/OL].(2023-10-28)[2023-11-05].http://cccl-tcm.cacm.org.cn/thesisDetails?columnId=43200280&Fpath=home&index=0 DOI:
病史摘要,2,患者,男,79岁,头痛、头晕2周,言语不利1周,发热1天。入院时意识模糊,摸索动作,发热,头痛,言语不利,右侧肢体活动不利,咳嗽咳痰,痰黄白相间,气喘,留置胃管,寐差,留置尿管,大便十日未解。舌质红,苔黄厚腻,脉弦滑有力。中医诊断 头痛 痰浊中阻、湿温闭窍证西医诊断 结核性脑膜脑炎;脑梗死急性期辅助检查 脑脊液压力:202 mmH2O;外观:黄色混浊、潘氏反应:阳性、白细胞1248×10,6,/L;氯:115.0 mmol/L、葡萄糖:1.91 mmol/L、蛋白:4286.0 mg/L↑。血浆结核感染T细胞(阳性),结核感染T细胞γ干扰:86.20。病院微生物高通量宏基因组测序分岐杆菌序列数:24,相对丰度:15.69 %;结核分歧杆菌复合群序列数22,相对丰度:14.38 %;头颅MRI+DWI:右侧基底节区及额叶急性腔隙性脑梗死。本病例为中西医协同联合诊治,中医方面:内服中药在湿温的不同阶段予以清热解毒、通腑泄热、健脾燥湿、芳香化湿、育阴利湿、滋阴增液、温通阳气等不同治法。西药方面 住院期间予病重通知,药物予四联抗结核及异烟肼注射液鞘内注射治疗、抗血小板聚集、调脂稳斑、改善循环、预防应激性溃疡、抗感染、脱水降颅压、控制心率等对症治疗。患者出院时神清语利,脑脊液各项指标较前均明显好转。血液和脑脊液:结核感染T细胞(阴性);结核感染T细胞γ干扰:0。病原微生物高通量宏基因组测序未检出。(详见图2,2022年1月28日第三方检测),自行行走出院(附视频)。出院后继续抗结核、抗血小板聚集、调脂稳斑、内服中药等治疗。至2023年1月9日随访1年,患者言语流利,自行行走,症状无复发,最终痊愈。中医诊断 头痛(痰浊中阻,湿温闭窍证)西医诊断 结核性脑膜脑炎;脑梗死急性期;消化道出血;慢性肾功能不全;高血压病3级(很高危组);心率失常(室上性心动过速 阵发性心房颤动);肝囊肿;左肾囊肿;左肾结石;脑萎缩;血脂异常;颈椎退行性变干预措施 中医以廓清湿温、温通阳气为法,辨证使用口服中药汤剂;西医以四联抗结核、抗血小板聚集,调脂稳斑,改善循环等对症治疗。疗效转归 神清,精神可,言语欠清、肢体活动不利明显改善,无头痛头晕,二便正常,自行步行出院。随访1年,目前患者无不适。
Summary of case history, The patient, a 79-year-old male, had headache and dizziness for 2 weeks, speech impairment for 1 week and fever for 1 day.On admission to hospital, The patient had many symptoms, including confusion, groping for movement, fever, headache, speech disorder, movement disorder on right limb, cough and sputum, and shortness of breath.Meanwhile, The patient had gastric and urinary tubes on her body, slept very poorly, and had constipation for ten days. His tongue is red, and the fur was thick and greasy. The pulse was like a string, smooth and strong.Admission diagnosis: Chinese medicine diagnosis: headache: The syndrome of obstruction in phlegm turbidity and dampness and temperature closing orifices.Modern medical diagnosis: Tuberculous meningoencephalitis ; acute cerebral infarction.Auxiliary examination: Cerebrospinal fluid pressure: 202 mmH2O; Appearance: Yellow and cloudy. Pandy Test: (+), WBC 1248×10^6/L↑; Cl: 115.0 mmol/L, G: 1.91 mmol/L, Pro: 4286.0 mg/L↑.T-SPOT (+), IGRAs(Interferon-Gamma Release Assay): 86.20.metagenomics next-generation sequencing (mNGS): Mycobacterium : Sequence number: 24, isotopic abundance ratio: 15.69 %; Mycobacterium tuberculosis complex: Sequence number: 22, isotopic abundance ratio: 14.38 %.MRI+DWI of Head: 1. Acute lacunar infarction in right basal ganglia and frontal lobe.This case is a joint diagnosis and treatment of traditional Chinese and western medicine.In terms of traditional Chinese medicine: In different stages of " the syndrome type of wet and warm", the use of treatments include clearing heat and detoxifying, relieving heat, invigorating spleen and drying dampness, aromatizing dampness, nourishing Yin and reducing dampness, nourishing Yin and increasing fluid, warming Yang qi.In terms of Western medicine: the patient was given notice of serious illness during hospitalization, and the patient was given quadruple anti-tuberculosis treatment, intrathecal injection of isoniazid injection, anti-platelet agglutination, lipid regulation and plaque stability, circulation improvement, stress ulcer prevention, anti-infection, dehydration and cranial pressure reduction, heart rate control and other symptomatic treatments.The patient's clinical symptoms were greatly improved, and the laboratory examination returned to normal, and then, the patient was discharged after recovery.After discharge, the patient continued to be treated with anti-tuberculosis, anti-platelet aggregation, lipid-regulating and plaque stabilization, and oral Chinese medicine. Finally, until January 9, 2022. The patient was fluent in speech, walked on his own, had no recurrence of symptoms,and had recovered.,TCM diagnosis, headache (The syndrome of obstruction in phlegm turbidity and dampness and temperature closing orifices),Western medicine diagnosis, tuberculous menioencephalitis;;acute stage of cerebral infarction;digestive tract hemorrhage;chronic renal insufficiency;grade 3 hypertension (very high-risk group);arrhythmia supraventricular tachycardia paroxysmal atrial fibrillation;liver cyst;left kidney cyst;left kidney stone ; brain atrophy ;dyslipidemia; cervical degenerative changes,Therapeutic methods, In traditional Chinese medicine, the method of clearing dampness temperature and warming Yang qi is used, and TCM decoction is used for syndrome differentiation. Western medicine is based on quadruple anti-tuberculosis, anti-platelet aggregation, lipid-regulating and plaque stabilizing, improving circulation and other symptomatic treatment.,Clinical outcomes, The patient was conscious and in good spirits. The symptoms such as slurred speech and poor physical activity were significantly improved. He had no headache or dizziness, and his stools and urination were normal. Within two years, the patient had no discomfort.
结核性脑膜脑炎临床病案湿温廓清湿温温通阳气
tuberculous meningoencephalitisclinical medical casedamp-heat syndromeremove moisture and heatwarm and dredge yang qi
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