Summary of case history,　2021-04 The patient developed bilateral lower extremity edema, hypoalbuminemia, massive proteinuria with hyperlipidemia without obvious incentives. Symptomatic and supportive treatment such as spironolactone, valsartan capsules, etc., but no glucocorticoid treatment was given, and renal biopsy was not performed due to severe abdominal edema. After regular outpatient follow-up, the urine protein was maintained at 2 to 4, serum albumin was 22 to 20.1 g/L, and serum creatinine was 73 to 93 μmol/L. He has a history of chronic viral hepatitis B for more than 19 years, and was diagnosed as decompensated stage of post-hepatitis B cirrhosis in 2021-05. The older brother suffers from chronic viral hepatitis and membranous nephropath. On 2021-11-01, he was hospitalized in our hospital and underwent renal biopsy. Kidney pathology: IgA nephropathy (Oxford classification: M1E1S1T1C1). Glucocorticoids combined with antiviral therapy, symptomatic and supportive therapy and Chinese medicine therapy were given. Three months later, the patient developed high fever, chest tightness and suffocation with a large amount of pleural and ascites. He was hospitalized in our hospital again, and glucocorticoids were discontinued, and only TCM syndrome differentiation was used. In the acute stage of the disease, the traditional Chinese medicine prescription Yinchen Qumai Chixiaodou Decoction was given orally at three doses in two days to quickly control the disease.,TCM diagnosis,　Edema, deficiency of spleen and kidney combined with damp-heat stasis and toxin syndrome,Western medicine diagnosis,　1. Nephrotic syndrome IgA nephropathy 2. Chronic hepatitis B virus 3. Decompensated stage of liver cirrhosis after hepatitis B.,Therapeutic methods,　The traditional Chinese medicine prescription was Yinchen Qumai Chixiaodou Decoction, and western medicine was given to antiviral and RAS inhibitor for symptomatic and supportive treatment.,Clinical outcomes,　Edema subsided, urinary protein decreased, hypoalbuminemia improved, electrolytes were normal, renal function was stable, and the patients quality of life and prognosis were improved.